1. Signaling Pathways
  2. Membrane Transporter/Ion Channel
  3. Proton Pump

Proton Pump

Proton pump is an integral membrane protein that is capable of moving protons across a biological membrane. Mechanisms are based on conformational changes of the protein structure or on theQ cycle. In cell respiration, the proton pump uses energy to transport protons from the matrix of the mitochondrion to the inter-membrane space. It is an active pump, that generates a protonconcentration gradient across the inner mitochondrial membrane, because there are more protons outside the matrix than inside. The difference in pH and electric charge (ignoring differences inbuffer capacity) creates an electrochemical potential difference that works similar to that of a battery or energy storing unit for the cell. The process could also be seen as analogous to cycling uphill or charging a battery for later use, as it produces potential energy. The proton pump does not create energy, but forms a gradient that stores energy for later use.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-119991
    AHR-9294
    Inhibitor
    AHR-9294 is an inhibitor of the H+ pump enzyme and H, K-ATPase. AHR-9294 inhibits acid secretion in vivo.
    AHR-9294
  • HY-103261R
    SCH28080 (Standard)
    Inhibitor
    SCH28080 (Standard) is the analytical standard of SCH28080. This product is intended for research and analytical applications. SCH28080 is a reversible, K+-competitive inhibitor of the gastric H,K-ATPase, with a Ki of 0.12 μM. SCH28080 is an effective inhibitor of acid secretion in vivo and with anti-gastric ulcer activity.
    SCH28080 (Standard)
  • HY-17421A
    Tenatoprazole sodium
    Inhibitor
    Tenatoprazole sodium (TU-199 sodium) is a proton pump inhibitor; inhibits hog gastric H+/K+-ATPase with an IC50 of 6.2 μM.
    Tenatoprazole sodium
  • HY-U00222
    S3337
    Inhibitor
    S3337 is an H+, K+-ATPase inhibitor.
    S3337
Cat. No. Product Name / Synonyms Application Reactivity